Oral Administration of Skin Gelatin Isolated from Chum Salmon (Oncorhynchus keta) Enhances Wound Healing in Diabetic Rats
نویسندگان
چکیده
Care for diabetic wounds remains a significant clinical problem. The present study was aimed at investigating the effect of skin gelatin from Chum Salmon on defective wound repair in the skin of diabetic rats. Full-thickness excisional skin wounds were made in 48 rats, of which 32 were diabetes. The diabetic rats were orally treated daily for 14 days with skin gelatin from Chum Salmon (2 g/kg) or its vehicle. Sixteen non-diabetic control rats received the same amount of water as vehicle-treated non-diabetic rats. Rats were killed to assess the rate of wound closure, microvessel density (MVD), vascular endothelial growth factor (VEGF), hydroxyproline (HP) contents in wound tissues and nitrate in plasma and wound tissue at 7 and 14 days after wounding. Skin gelatin-treated diabetic rats showed a better wound closure, increased MVD, VEGF, hydroxyproline and NO contents and a reduced extent of inflammatory response. All parameters were significant (P < 0.05) in comparison to vehicle-treated diabetic group. In light of our finding that skin gelatin of Chum Salmon promotes skin wound repair in diabetic rats, we propose that oral administration of Chum Salmon skin gelatin might be a beneficial method for treating wound disorders associated with diabetes.
منابع مشابه
Oral administration of marine collagen peptides prepared from chum salmon (Oncorhynchus keta) improves wound healing following cesarean section in rats
BACKGROUND The goal of the present study was to investigate the wound-healing potential of marine collagen peptides (MCPs) from chum salmon skin administered to rats following cesarean section (CS). METHODS Ninety-six pregnant Sprague-Dawley rats were randomly divided into four groups: a vehicle group and three MCP groups. After CS, rats were intragastrically given MCPs at doses of 0, 0.13, 0...
متن کاملDetermination of population structure and stock composition of chum salmon (Oncorhynchus keta) in Russia determined with microsatellites
In Asia, there are two distinct types of chum salmon (Oncorhynchus keta Walbaum). The early-maturing or “summer” chum salmon generally returns to spawn from June through August in streams bordering Kamchatka, the Sea of Okhotsk, the east coast of Sakhalin Island, and the Amur River. Later-maturing or “autumn” chum salmon generally return to spawn from September through November in streams in Ja...
متن کاملDetection of Flavobacterium psychrophilum in Chum Salmon Oncorhynchus keta and Virulence of Isolated Strains to Salmonid Fishes
We investigated the presence of Flavobacterium psychrophilum in the ovarian fluids of female adults (eight rivers) and the fry kidney tissues (nine hatcheries) of chum salmon Oncorhynchus keta in Hokkaido, Japan in 2005. F. psychrophilum was detected by culture in 3.3– 90.0% of ovarian fluid at all rivers and 5% of kidney tissue at one hatchery, whereas 33.3–100% and 5.0–42.5%, respectively, at...
متن کاملPharmacological Activity and Clinical Use of PDRN
PDRN is a proprietary and registered drug that possesses several activities: tissue repairing, anti-ischemic, and anti-inflammatory. These therapeutic properties suggest its use in regenerative medicine and in diabetic foot ulcers. PDRN holds a mixture of deoxyribonucleotides with molecular weights ranging between 50 and 1,500 KDa, it is derived from a controlled purification and sterilization ...
متن کاملReproduction of Short-Term Vertical Movements Observed Using Archival Tags on Chum Salmon (Oncorhynchus keta) by a Simple Model
Vertical movement patterns of chum salmon (Oncorhynchus keta) during their homing migration were examined using archival tags. Vertical movements through the thermocline with a periodicity of less than 1 h were observed during the day in the North Pacific. To examine the dynamics of these short-term vertical movements, we developed a simple one-dimensional vertical movement model. It is assumed...
متن کامل